Sunday, June 23, 2013

Stocks recover on Wall Street after a 2-day plunge

Traders decided that the stock market has suffered enough, at least for now.

After a two-day plunge, stocks ended the week with an advance on Friday, suggesting that Wall Street may be successfully weaned from the Federal Reserve's easy money after all.

"Saner heads are prevailing," said Jim Dunigan, chief investment officer at PNC Wealth Management. "People are looking a little deeper into the message from the Fed ? the economy is getting better," he said. "At the end of the day that's a positive."

The Fed's move also pushed up the yield on the 10-year Treasury note to the highest level in almost two years as investors bet that U.S. interest rates will rise.

Investors had known that sooner or later the Fed would quit spending $85 billion per month pumping money into the U.S. economy.

That money has been a big driver behind the stock market's bull run the last four years. It led to low interest rates that encouraged borrowing for everything from factory machinery to commercial airplanes to home renovations. Has the economy been great? No. Unemployment is still high and U.S. growth has been anemic. But it could have been worse. Investors were confident enough in a growing economy that the Standard & Poor's 500 index hit an all-time high of 1,669 on May 21.

Then on Wednesday, the Fed said it would aim to turn off that spigot by the middle of next year as long as the economy is strong enough.

Just because investors knew it was coming didn't mean they liked it. The Dow dropped 560 points on Wednesday and Thursday.

Investors recovered their mojo on Friday. The Dow Jones industrial average rose 41.08 points, or 0.3 percent, to close at 14,799.40. The Standard & Poor's 500 index rose 4.24 points, or 0.3 percent to close at 1,592.43.

The gains were led by the kinds of stocks that investors favor when they want to play it safe. Makers of consumer staples, utilities, and health care companies rose the most of the 10 industries in the S&P 500 index. The only two categories that fell were technology stocks and companies that make basic materials.

Friday's gain wasn't enough to erase the market's loss for the week. The S&P 500 fell 2.1 percent for the week, and the Dow was down 1.8 percent. Stocks have now fallen two weeks in a row, and four of the past five.

The real question will be whether the sell-off continues next week, said Frank Fantozzi, CEO of Planned Financial Services. So far, the market's swoon this week appears to be more of an adjustment than the beginning of a long-term rout. "If the flow out of equities starts to increase, this might be the pullback we've been waiting for," he said.

Many investors have been predicting some kind of pullback in the market following its nearly unbroken advance since last fall. The S&P 500 index rose for seven straight months through May. So far in June it's down 2.1 percent.

The yield on the 10-year Treasury note hit 2.54 percent, up from 2.42 percent late Thursday. It has risen sharply since Wednesday as investors sold bonds in anticipation that the Fed would slow, and eventually end, its bond purchases, if the U.S. recovery continues.

The yield, which is a benchmark for interest rates on many kinds of loans including home mortgages, was as low as 1.63 percent as recently as May 3.

Technology shares lagged the market after business software maker Oracle reported flat revenue late Thursday, even though analysts expected an increase. Oracle plunged $3.07, or 9 percent, to $30.14, the biggest drop in the S&P 500 index. Oracle is struggling to adapt as customers shift away from software installed on their own computers toward software that runs remotely.

The Nasdaq composite index, which is heavily weighted with technology stocks, fell 7.39 points, or 0.2 percent, to 3,357.25. Apple, the biggest stock in the index, fell $3.34, or 0.8 percent, to $413.50. Microsoft fell 23 cents, or 0.7 percent, to $33.27.

The price of gold recovered after plunging the day before. Gold rose $5.80, or 0.5 percent, to $1,292 an ounce. Crude oil fell $1.45, or 1.5 percent, to $93.69 a barrel in New York.

The dollar rose against other currencies as traders anticipated that U.S. interest rates would rise as the Fed winds down its bond purchases.

Among other stocks making big moves:

?Darden Restaurants, which runs Olive Garden and Red Lobster, fell $1.11, or 2 percent, to $50.12 after rising expenses hurt its fourth-quarter earnings.

? Spreadtrum Communications jumped $3.62, or 16 percent, to $25.91 after the Chinese smartphone chip maker said its board is considering a buyout offer valued at about $1.39 billion from Tsinghua Holdings.

? Facebook rose 63 cents, or 2.6 percent, to $24.53 after saying it will add video to its popular photo-sharing app Instagram, following on the heels of Twitter's growing video-sharing app, Vine.

A Fed policy statement and comments from Fed Chairman Ben Bernanke started the selling in stocks, bonds and commodities Wednesday. Bernanke said the Fed expects to scale back its bond-buying program later this year and end it by mid-2014 if the economy continues to improve. The bank has been buying Treasury and mortgage bonds, which has made borrowing cheap for consumers and businesses. The program has also encouraged investors to buy stocks instead of bonds.

The S&P 500 is still up 11.7 percent, for the year, not far from its full-year increase of 13.4 percent last year.

___

AP Business Writer Bernard Condon contributed.

Source: http://news.yahoo.com/stocks-recover-wall-street-2-day-plunge-205821850.html

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Saturday, June 22, 2013

Lifetime takes liberties with Jodi Arias movie

TV

6 hours ago

The Jodi Arias murder trial was must-watch TV for five months this year because it had everything: young beautiful people; sex, lies, photos and audiotapes; religious obstacles; and a particularly heinous tragic ending.

A month after a jury could not decide unanimously if the convicted murderer should be sentenced to death, Lifetime taking the story of Travis Alexander?s brutal death to the small screen. ?Jodi Arias: Dirty Little Secret,? a title inspired by Arias? lawyer?s opening argument, premieres Saturday at 8 p.m. The two-hour film starring Tania Raymonde (?Lost?) as Arias and Jesse Lee Soffer (?The Mob Doctor?) as Alexander covers their turbulent and brief relationship more than it does the courtroom drama.

Arias, 32, spent 18 days on the witness stand, where she shared sordid details of every intimate relationship she?s been in as well as her time with Alexander. From her favorite drinks and snacks to her many trips with Alexander to their dirty talk and Tootsie Pops and Pop Rocks trysts, Arias left nothing out?except for a plausible explanation for why she killed a man she said she wanted to marry. Along the way, we heard all the lies Arias told the police, media and anyone who would listen before, during, and after the murder. Then she told some more to the jury.

If there was one story that did not need embellishing, it was this one. But "Dirty Little Secret" co-writers Richard Blaney and Gregory Small do take some creative licenses and fill in a few blanks the trial did not cover. What's real and what's not? Here's your guide to five of the larger departures. Spoiler alert!

1.Las Vegas, 2006

TRIALFACT: Arias and Alexander met in Sin City at the first Prepaid Legal Services convention she attended. She testified that he made a beeline to introduce himself at a mixer and later invited her to a dinner for executives as his guest. Because he was so ?attentive,? she said she had to tell him that she lived with her boyfriend and was ?monogamous.?

FILMFICTION: As Alexander gives a speech at a conference about ?putting a bull's-eye? on what you want and not letting anything get in the way, Arias is in the audience taking in every syllable. When he finishes and retreats to the men?s room, she follows him inside. ?I just want you to know that I think you?re amazing,? she says as she barges in and he?s standing at the urinal. Could Arias have been nutty enough to introduce herself to Alexander this way? Perhaps if she had, Alexander would have stayed clear of her.

2.Sexual Encounter No. 1

FACT: After the Las Vegas conference, Arias went home to Palm Desert, Calif., and broke up with her boyfriend. Four days later, she and Alexander met at a friend?s house in Temecula, Calif., where he snuck into her room in the middle of the night and gave her oral sex, she testified. She removed his Mormon temple garments and returned the favor. ?There was no conversation,? she testified. ?I thought there was going to be, but there wasn?t. We sat down and started passionately kissing?I was apprehensive but I was going with it. I didn?t want to tell him no.?

FICTION: During a very awkward conversation full of cheesy sexual innuendos, Arias comes on to Alexander and invites herself to his hotel room to ?drink coffee.? Alexander responds by giving her a little pep talk about why she blows him away and he must refuse. The next night, however, Alexander drinks his coffee. Black.

3.Alexander?s best friends warn him to break up with Arias

FACT: Although Chris Hughes, Alexander?s best friend, was not asked about this incident when he testified, he and his wife appeared regularly on HLN during the trial and told the story of the night Arias scared them to the point they asked her never to return to their house again. While Arias was supposed to be sleeping in the middle of the night, they had a talk with Alexander in their bedroom about their concerns about her bizarre and possessive behavior. Sky Hughes said she felt a bad vibe and told Alexander to open the door. Arias, who had been eavesdropping, was standing there and gave them a ?creepy? look that frightened them enough to tell her to stay away.

FICTION: Sitting by Alexander?s pool, the Hughes talk to Alexander about Arias? obsessive behavior. ?We don?t like her for you.? Alexander responds by saying they don?t need to worry because he?s not in it for the long-term. Arias opens the door and startles them. She and Alexander then get into a fight. ?You think I?m gonna be your booty call forever? If so, man up and tell me,? she begs. Alexander breaks up with her. But it doesn?t end there.

4.The Day of the Murder

FACT: In April 2008, Arias packed up her things and moved to Yreka, Calif., to live with her grandparents. On June 4, 2008, while supposedly en route to Utah on Prepaid Legal business, Arias drove 1000 miles to Alexander?s home in Mesa, Arizona, arriving around 4 a.m. Thirteen hours later, she slashed his throat, stabbed him 28 other times and shot him once in the head and then drove to Utah where she made out with another man.

FICTION: At one point after their break-up, Arias is shown in Yreka, Calif. at her grandparents? house, holding her grandfather?s gun. But then Arias shows up at Alexander?s Arizona house around midnight on June 4, 2008 and tells him she is there to say goodbye because she is moving to Yreka. After some weird talk about how easy she is to be with, Alexander asks her if she wants to spend the night.

5.Travis Alexander?s Death

FACT: We will never know exactly why Arias killed Alexander unless she decides to fess up. She said their fight started when she accidentally dropped the camera after they?d spent the afternoon having sex and photographing one another. The prosecution argued it was all a pre-meditated set-up as Arias was in a jealous rage because he was going to Cancun, Mexico, with another woman. If Arias couldn?t have him, nobody could, the prosecution argued.

FICTION: A text from Katie (his new girlfriend) asking Alexander to meet to talk sends Arias into a rage as Alexander begins to shower. Angrily, Arias directs Alexander to pose for pictures in the shower until she gets him into the vulnerable position she is seeking. Within minutes, his life is over as she surprises him with the knife and later shoots him.

Our Verdict

Raymonde does an admirable job of channeling Arias' crazy-behind-the-eyes behavior trial followers heard described nightly on HLN as well as her insecurities. But Soffer doesn't do justice to Alexander's charisma and swagger, so it's hard to buy her obsession with him. The movie probably would have benefitted from some distance from the irresistible trial. Too much of this sad saga is engrained in our minds.

Source: http://www.today.com/entertainment/true-or-false-lifetime-takes-liberties-jodi-arias-movie-6C10345062

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Remembering James Gandolfini With This Classic Scene From 'True Romance'

Yesterday, we lost one of our very best actors, James Gandolfini, who died of an alleged heart attack while on vacation in Italy at the age of 51. Gandolfini will always be best known for his role on "The Sopranos," but a scene in "True Romance" perfectly captures everything he brought to the screen. The [...]

Source: http://moviesblog.mtv.com/2013/06/20/james-gandolfini-dead-true-romance/

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Aviary 3.0 for Android features new interface and photo filters

DNP Aviary 30 for Android features better Enhance tool, new photo filters

Now that Aviary has been on its own for a year, its developers have seen it fit to give its Android app a modest overhaul. Aviary version 3.0 packs in a new interface, an improved focus tool, a beefed up color splash feature and an array of goofy stickers. The Enhance tool has also been expanded to offer three distinct options -- Hi-Def, Illuminate and Color Fix -- each tweaking your photo's sharpness, brightness and color settings, respectively. Aviary's filters went through a renovation as well, with the developers adding the erstwhile iOS-only Woodlands Effect Pack as an in-app purchase. Head on over to Google Play or click the source links below to download the app -- it was good enough for Jeff Bezos, so it might have the potential to win your photo-filter-loving heart.

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Via: CNET

Source: Aviary, Google Play

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/-vUPwMKZX-I/

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Pluripotent stem cells made from pancreatic cancer cells are first human model of the cancer's progression

June 20, 2013 ? Pancreatic cancer carries a dismal prognosis. According to the National Cancer Institute, the overall five-year relative survival for 2003-2009 was 6 percent.

Still, researchers and clinicians don't have a non-invasive way to even detect early cells that portent later disease. 'There's no PSA test for pancreatic cancer,' they say, and that's one of the main reasons why pancreatic cancer is detected so late in its course. They have been searching for a human-cell model of early-disease progression. Now, Perelman School of Medicine, University of Pennsylvania scientists have used stem-cell technology to create a research cell line from a patient with advanced pancreatic ductal adenocarcinoma (PDAC).

This first-of-its-kind human-cell model of pancreatic cancer progression was published this week in Cell Reports from the lab of Ken Zaret, PhD, professor of Cell and Developmental Biology.

"It is the first example using induced pluripotent stem [iPS] cells to model cancer progression directly from a solid tumor, and the first human cell line that can model pancreatic cancer progression from early to invasive stages," says Zaret, also the associate director of the Penn Institute for Regenerative Medicine.

"We were able to predict the appearance of cellular features and protein markers in the intermediate stages of pancreatic cancer that are not evident in the terminal stages. This has given us new perspectives into what this deadly type of cancer looks like -- something no one has seen before in human cells. Our analysis revealed known molecular networks that are activated during PDAC progression, as well as a new molecular network that is activated during the intermediate stages. This could provide a fresh outlook on biomarkers for early stages of the disease."

A Leap of Faith

Zaret and first author Jungsun Kim, PhD, a postdoctoral associate in the Zaret lab, hypothesized that if human PDAC cells were reprogrammed back to pluripotent cells and then allowed to re-differentiate into pancreatic tissue, they might undergo the early stages of cancer. To do this, they created the PDAC pluripotent cells and indeed found that they recapitulated the early to intermediate stages of pancreatic cancer. They then isolated the cells at the early stage, cultured the cells in vitro, and identified the secreted and released proteins that might serve as early-stage biomarkers of disease progression.

There's one caveat, though, says Zaret. "Using the iPS method, we could only get a cancer cell line from one patient to reprogram, meaning this work is representative of one individual's cancer," noting that his close collaboration with John Hoffman, a surgeon from the Fox Chase Cancer Center (FCCC) was key in order to get fresh cancer cells for the reprogramming. They tried this method with cells from nine human tumors in total. However, as Zaret points out, there are many examples of where a single human cell line has served as a highly useful model for human disease.

"Our iPS-like cells exhibited pluripotency, like other stem cells, but when they differentiated after we injected them into the immunodeficient mice, they preferentially developed into early-stage pancreatic cancer cells," says Zaret. He explains that the approach is another example of using iPS cells from human patients to model disease, by capturing the genome of an affected individual. However, this is a first in solid tumor cancers, whereas many other labs have developed these types of cell lines for neurological and cardiovascular disorders.

The visual characteristics of these cancer cells -- as they progress from early- to late-stage cancer -- are typical of what is seen in cells analyzed from cancer patients in the clinic now. In the early stage, pancreatic ducts have lesions with cells of an abnormal shape, and express characteristic proteins as measured by stains. Over time, some of these aberrant cells may grow excessively, lose their ductal characteristics, and become invasive.

When the human PDAC iPS cells are grown as lesions in the mouse, they secrete or release proteins corresponding to protein networks expressed during the progression of human pancreatic cancer, namely molecules centered on a trio of key proteins: HNF4, integrin, and TGFbeta.

"We propose to look in the blood of potential pancreatic cancer patients or relatively early-stage patients for the biomarkers we found downstream of these molecular networks, to see if they are present in people," says Zaret.

The Making of a Model

This approach allows human cells to be studied directly, as opposed to examining characteristics of pancreatic cancer progression in an animal model and then having to assess whether the findings apply to humans. The cells harvested from the cancer patient were reprogrammed using the four Yamanaka factors carried in a lentivirus, which was adapted by the Zaret lab.

To see what the reprogramming did at a genetic level, the team compared the genomic structure of the early iPS pancreatic cancer cell line to original tumor cells from which the cell line was isolated. They found 23 chromosomal aberrations in the primary tumor cells as compared to 20 of the same chromosomal aberrations in the PDAC iPS line, demonstrating that the PDAC iPS line was derived from the original tumor cells.

By contrast, no chromosomal abberations were seen in cells taken from the margin of the tumor in a cancer-free part of the pancreas from the patient, as well as from an iPS line that the Zaret group made from the margin cells.

These sets of comparisons allowed the team to directly observe the changes in the pancreatic cancer cell line versus a normal cell line derived from the same human genetic background.

"We understand that the pancreatic cancer field has been dogged by searching for unique markers in the blood that detect disease early, and we hope that this live-cell progression approach will gives us a new way to see early molecular markers for pancreatic cancer," says Zaret.

"Since we can detect released protein markers of at least three different networks from the early-stage human lesions in our model, we think that looking for blood markers of the simultaneous activation the three pathways, instead of a single marker, could provide better leverage in detection. The new model could also be used to test drugs that block the intermediate stages of the disease. We would also like to know how we got lucky with this one cell line, so that the iPS technology can be adapted to model other human cancers." The research was funded by the National Institute for General Medical Sciences through an NIH Merit award (R37GM36477)

Other co-authors are R. Katherine Alpaugh, Andrew D. Rhim, Maximilian Reichert, Ben Z. Stanger, Emma E. Furth, Antonia R. Sepulveda, Chao-Xing Yuan, Kyoung-Jae Won, Greg Donahue, and Jessica Sands, all from Penn, and Andrew A. Gumbs, from FCCC.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/_Iz7BTiIlUo/130620132105.htm

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Friday, June 21, 2013

A battery made of wood?

June 19, 2013 ? A sliver of wood coated with tin could make a tiny, long-lasting, efficient and environmentally friendly battery.

But don't try it at home yet -- the components in the battery tested by scientists at the University of Maryland are a thousand times thinner than a piece of paper. Using sodium instead of lithium, as many rechargeable batteries do, makes the battery environmentally benign. Sodium doesn't store energy as efficiently as lithium, so you won't see this battery in your cell phone -- instead, its low cost and common materials would make it ideal to store huge amounts of energy at once, such as solar energy at a power plant.

Existing batteries are often created on stiff bases, which are too brittle to withstand the swelling and shrinking that happens as electrons are stored in and used up from the battery. Liangbing Hu, Teng Li and their team found that wood fibers are supple enough to let their sodium-ion battery last more than 400 charging cycles, which puts it among the longest lasting nanobatteries.

"The inspiration behind the idea comes from the trees," said Hu, an assistant professor of materials science. "Wood fibers that make up a tree once held mineral-rich water, and so are ideal for storing liquid electrolytes, making them not only the base but an active part of the battery."

Lead author Hongli Zhu and other team members noticed that after charging and discharging the battery hundreds of times, the wood ended up wrinkled but intact. Computer models showed that that the wrinkles effectively relax the stress in the battery during charging and recharging, so that the battery can survive many cycles.

"Pushing sodium ions through tin anodes often weaken the tin's connection to its base material," said Li, an associate professor of mechanical engineering. "But the wood fibers are soft enough to serve as a mechanical buffer, and thus can accommodate tin's changes. This is the key to our long-lasting sodium-ion batteries."

The team's research was supported by the University of Maryland and the U.S. National Science Foundation.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/lGAYwYYOa2A/130619195221.htm

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Feel Better Fast: Superfoods For Pain Relief - Weather.com

www.weather.com:

When cold, rainy days or tough workouts trigger muscle and joint pain, most people reach for an NSAID - or an over-the-counter non-steroidal anti-inflammatory drug, such as aspirin and ibuprofen - to reduce pain and inflammation.

Read the whole story at www.weather.com

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Source: http://www.huffingtonpost.com/2013/06/19/feel-better-fast-superfoo_n_3466383.html

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