Hair analysis reveals elevated stress hormone levels raise cardiovascular risk

Public release date: 17-Apr-2013
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Contact: Jenni Glenn Gingery
jgingery@endo-society.org
301-941-0240
The Endocrine Society

Long-term cortisol exposure in seniors linked to heart disease, stroke

Chevy Chase, MDHair strands contain valuable information about senior citizens' stress levels that can be used to determine an individual's cardiovascular disease risk, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Unlike a blood test that captures a snapshot of stress hormone levels at a single point in time, a scalp hair analysis can be used to view trends in levels of the stress hormone cortisol over the course of several months. This approach allows researchers to have a better sense of the variability in cortisol levels. The study found seniors who had higher long-term levels of the stress hormone cortisol were more likely to have cardiovascular disease.

"Like high blood pressure or abdominal fat, the findings suggest elevated cortisol levels are an important signal that an individual is at risk of cardiovascular disease," said one of the study's lead authors, Laura Manenschijn, MD, of Erasmus MC in Rotterdam, The Netherlands. "Because scalp hair can capture information about how cortisol levels have changed over time, hair analysis gives us a better tool for evaluating that risk."

The study measured cortisol levels in a group of 283 community-dwelling senior citizens between the ages of 65 and 85. Participants were randomly selected from a large population-based cohort study. Using 3-centimeter-long hair samples taken from close to the scalp, researchers were able to measure cortisol levels from a three-month period. People with high cortisol levels were more likely to have a history of coronary heart disease, stroke, peripheral arterial disease or diabetes.

"The data showed a clear link between chronically elevated cortisol levels and cardiovascular disease," said the study's other lead author, Elisabeth van Rossum, MD, PhD, of Erasmus MC. "Additional studies are needed to explore the role of long-term cortisol measurement as a cardiovascular disease predictor and how it can be used to inform new treatment or prevention strategies."

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Other researchers working on the study include: L. Schaap, N. van Schoor, S. van der Pas, G. Peeters and P. Lips of VU University Medical Center, and J. Koper of Erasmus MC.

The article, "High Long-Term Cortisol Levels, Measured in Scalp Hair, are Associated with a History of Cardiovascular Disease," appears in the May 2013 issue of JCEM.

Founded in 1916, The Endocrine Society is the world's oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, The Endocrine Society's membership consists of over 16,000 scientists, physicians, educators, nurses and students in more than 100 countries. Society members represent all basic, applied and clinical interests in endocrinology. The Endocrine Society is based in Chevy Chase, Maryland. To learn more about the Society and the field of endocrinology, visit our site at http://www.endo-society.org. Follow us on Twitter at https://twitter.com/#!/EndoMedia.

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Public release date: 17-Apr-2013
[ | E-mail | Share ]

Contact: Jenni Glenn Gingery
jgingery@endo-society.org
301-941-0240
The Endocrine Society

Long-term cortisol exposure in seniors linked to heart disease, stroke

Chevy Chase, MDHair strands contain valuable information about senior citizens' stress levels that can be used to determine an individual's cardiovascular disease risk, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Unlike a blood test that captures a snapshot of stress hormone levels at a single point in time, a scalp hair analysis can be used to view trends in levels of the stress hormone cortisol over the course of several months. This approach allows researchers to have a better sense of the variability in cortisol levels. The study found seniors who had higher long-term levels of the stress hormone cortisol were more likely to have cardiovascular disease.

"Like high blood pressure or abdominal fat, the findings suggest elevated cortisol levels are an important signal that an individual is at risk of cardiovascular disease," said one of the study's lead authors, Laura Manenschijn, MD, of Erasmus MC in Rotterdam, The Netherlands. "Because scalp hair can capture information about how cortisol levels have changed over time, hair analysis gives us a better tool for evaluating that risk."

The study measured cortisol levels in a group of 283 community-dwelling senior citizens between the ages of 65 and 85. Participants were randomly selected from a large population-based cohort study. Using 3-centimeter-long hair samples taken from close to the scalp, researchers were able to measure cortisol levels from a three-month period. People with high cortisol levels were more likely to have a history of coronary heart disease, stroke, peripheral arterial disease or diabetes.

"The data showed a clear link between chronically elevated cortisol levels and cardiovascular disease," said the study's other lead author, Elisabeth van Rossum, MD, PhD, of Erasmus MC. "Additional studies are needed to explore the role of long-term cortisol measurement as a cardiovascular disease predictor and how it can be used to inform new treatment or prevention strategies."

###

Other researchers working on the study include: L. Schaap, N. van Schoor, S. van der Pas, G. Peeters and P. Lips of VU University Medical Center, and J. Koper of Erasmus MC.

The article, "High Long-Term Cortisol Levels, Measured in Scalp Hair, are Associated with a History of Cardiovascular Disease," appears in the May 2013 issue of JCEM.

Founded in 1916, The Endocrine Society is the world's oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, The Endocrine Society's membership consists of over 16,000 scientists, physicians, educators, nurses and students in more than 100 countries. Society members represent all basic, applied and clinical interests in endocrinology. The Endocrine Society is based in Chevy Chase, Maryland. To learn more about the Society and the field of endocrinology, visit our site at http://www.endo-society.org. Follow us on Twitter at https://twitter.com/#!/EndoMedia.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-04/tes-har041513.php

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